Research
Dr Sandeep Sreedharan has always been an avid researcher and is one of the few medical doctors in India with a masters degree in Human Genetics. Under the guidance of the legendary Padma Shri Dr V Mohan, Dr Sandeep did extensive research in the genetic aspects of type 2 diabetes and insulin resistance in South Indians. As a part of his Post-doctoral Fellowship training at Centre for Human Nutrition, Department of Internal Medicine, University of Texas SouthWestern Medical Centre, Dallas he continued his research on diabetes and obesity in South Asians in compared to other ethnic groups. The research included molecular genetic studies and the complex euglycemic hyperinsulinemic clamp studies, which were done under the mentorship of Dr Manisha Chandalia and Dr Nicola Abate, professors at the UTSW Medical Centre, Dallas.
Dr Sandeep is one of the co-authors of the first ICMR-WHO atlas of Diabetes in India and has published articles in several highly rated international journals. He was also awarded the ICMR Senior Research Fellowship for the project titled ICMR Young Diabetes Registry at The Madras Diabetes Research Foundation, Chennai for the years 2006-2008. He has also co-authored chapters in several textbooks.
He continues his research even as a busy practicing Nephrologist, on various aspects of Kidney Diseases and renal transplantation. He has been instrumental in initiating various research projects in Onconephrology at AIMS, Kochi. He has more than 50 publications in peer reviewed national and international journals and also has done numerous presentations in national and international conferences.
Dr Sandeep was also the executive editor of Amrita Journal of Medicine, the official journal of Amrita Institute of Medical Sciences and also serves as Editorial Board Member and reviewer in various peer reviewed journals. He is currently actively involved in promoting and undergraduate and postgraduate research programmes at Malabar Medical College.
Dr Sandeep’s research pages
Publications
Sandeep S, Mohan V. Assessing Insulin Resistance: An Overview. Indian Journal of Endocrinology & Metabolism. 2004; 1:24-31.
Anjana Mohan, Sandeep S, Deepa R, Vimaleswaran KS, Farooq S, Mohan V. Visceral and Central abdominal fact and anthropometry in relation to diabetes in Asian Indians. (CURES-7). Diabetes Care. 2004; 27:2948-2953
Nicola Abate, Chandalia M, Satija P, Adams-Huet B, Grundy SM, Sandeep S, Radha V, Deepa R, Mohan V. ENPP1/PC-1 K1 21Q Polymorphism and genetic susceptibility to Type 2 diabetes. Diabetes. 2005;54:1207-1213.
Deepa R, Sandeep S, Mohan V. Abdominal obesity, visceral fat and Type 2 diabetes - "Asian Indian Phenotype". In: Type 2 Diabetes in South Asians : Epidemiology, Risk Factors and Prevention. Mohan V, Gundu HR Rao (Eds), Under the Aegis of SASAT. Jaypee Brothers Medical Publishers. 2006;p.138-15
Mohan V, Gokulakrishnan K, Sandeep S, Srivastava BK, Ravikumar R, Deepa R. Intimal media thickness, glucose intolerance and metabolic syndrome in Asian Indians – the Chennai Urban Rural Epidemiology Study (CURES-22). Diabetic Medicine. 2006;23:845-850
Mohan V, Sandeep S, Deepa M, Gokulakrishnan K, Datta M, Deepa R. A diabetes risk score helps identify metabolic syndrome and cardiovascular risk in Indians- the Chennai Urban Rural Epidemiology Study (CURES-38). Diabetes Obesity Metabolism. 2007;9:337-343.
Sandeep S, Velmurugan K, Deepa R, Mohan V. Serum visfatin in relation to visceral fat, obesity and type 2 diabetes in Asian Indians (CURES-40). Metabolism 2007; 56:565-570.
Mohan V, Sandeep S. Rosiglitazone - Where do We stand Now?. The Asian Journal of Diabetology. 2007;9:31-35.
Mohan V, Sandeep S. ADOPT and DREAM trials and the Indian perspective. Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 2007;1:189-192.
Mohan V, Sandeep S, Deepa R. The Role of the Indian Diabetes Risk Score (IDRS) in Prevention of Type 2 Diabetes in India. The Antiseptic. 2007;104:193-197.
Mohan V, Sandeep S, Deepa R, Shah B, Varghese C. Epidemiology of type 2 diabetes: Indian Scenario?.Indian Journal of Medical Research. 2007;125:217-230.
Sandeep S, Mohan V. Changing Trends in Epidemiology of Diabetes. In : Medicine Update. Bichile SK (Ed), The Association of Physicans of India, 2008; 18:p.133 -141
Sandeep S, Gokulakrishnan K, Velmurugan K, Deepa M, Mohan V. Visceral and subcutaneous abdominal fat in relation to insulin resistance and metabolic syndrome in non-diabetic south Indians. Indian Journal of Medical Research. 2010;131;629-635.
Sandeep S, Gokulakrishnan K, Deepa M, Mohan V. Insulin Resistance is associated with increased cardiovascular risk in Asian Indians with normal glucose tolerance – The Chennai Urban Rural Epidemiology Study (CURES-66). Journal of Association of Physicians of India. 2011; 59:480-484
Sandeep Sreedharan, Baiju Faizal, Manohar. R, M. Gopalakrishna Pillai. Serum Lactate as an early indicator of mortality in critically ill patients with Sepsis. Kerala Medical Journal. 2011; 6: 31-35
Sandeep Sreedharan, RV Jayakumar. Prevention of diabetes in children In: “Diabetes in Children and adolescents”. RV Vijayakumar, Nisha Bhavani, Praveen V Pavithran (Ed). Jaypee brothers medical Publishers (P) Ltd. 2013 pp: 187- 201
S. Sandeep, M Srija, P.P Shilpa, A Mathew, R. Rajesh, G. Kurian, B. Nair, G. Kumar, K.R Nair, G. Mathew, K.V Sanjeevan, R.Varghese, L Kumar, S Sudhindran, A Thomas, VN Unni. Kidney transplantation - Experience at Amrita Hospital. Amrita Journal of Medicine. 2013; 9: 24-28
Vishnu Dev U, Sreedharan S, Bindhu M.R, Mathew A, Rajesh R, Kurian G, Unni V.N. Lung Cancer Presenting as Hyponatremia Amrita Journal of Medicine. 2013; 9: 35-37
Sandeep S, Unni VN, Sreekumar KP, Mathew A, Nair RR, Kurian G. Takayasu arteritis in an infant. Indian J Nephrol 2014; 24:257-9.
Ganesh, Kartik*,; Kurian, George; Sreedharan, Sandeep; Paul, Zachariah; Mathew, Anil; Unnikrishnan, U. G.1; Nair, Rajesh R.. Impact of Renal Transplant on Gonadal Function. Indian Journal of Transplantation 11(4):p 175-180, Oct–Dec 2017.
Ganesh K, Sreedharan S, Paul Z, Mathew A, Kurian G, Nair R. Profile of Pediatric Kidney Transplantation at a Tertiary Care Centre in Southern India. J Ped. Nephrology 2017; 5(1)
Reshma Abraham, Sandeep Sreedharan, Zachariah Paul, Anil Mathew, George Kurian, Rajesh R. Nair. Structural and Functional Changes in the Heart in Patients with Chronic Kidney Disease on Hemodialysis. Urology, Nephrology Andrology International. Volume 2, Issue 1, January - June 2017, Pages 17-20
Amrithapriya K, Sandeep Sreedharan, Simi S Nair, Zachariah Paul, Anil Mathew, George Kurian, Rajesh R Nair. Comparison of Adequacy of Hemodialysis in Patients with Dual lumen Tunneled Catheter and Arteriovenous Fistula. Amrita Journal of Medicine. Vol. 13, No: 3 Jul - Sep 2017, Page 15 – 17
Kartik Ganesh, Rajesh Nair, George Kurian, Anil Mathew, Sandeep Sreedharan, Zachariah Paul. Posterior Reversible Encephalopathy Syndrome in Kidney Disease. Kidney International Reports.2017;54(21)2753
Ganesh K, Nair R R, Seethalekshmy N V, Kurian G, Mathew A, Sreedharan S, Paul Z. A study of clinical presentation and correlative histopathological patterns in renal parenchymal disease. Indian J Nephrol 2018;28:28-34
Vishnu R.S, Sandeep Sreedharan, Zachariah Paul Polachirakkal, Anil Mathew, George Kurian, Rajesh Nair. Indications and Long Term Outcomes of Plasmapheresis in Neurological Disorders. Urology, Nephrology Andrology International. Volume 3, Issue 1, January- June 2018, Pages 11-14
Venkatesan, M., Mathew, A., Nair, R., Kurian, G., Seethalekshmy, N. V., Sreedharan, S. Paul, Z. (2019). IgA nephropathy presenting with pulmonary thromboembolism and renal artery infarct. Journal of Nephropathology, 8(3), 1-4.
Sreedharan S, Mathew A, Paul Z, Mathew N, Sundaram KR, Kurian G, Nair R. Changes in Left Ventricular Mass and Cardiovascular Risk Factors after Kidney Transplantation. Saudi J Kidney Dis Transpl. 2020 Sep-Oct;31(5):1006-1013.
Shabeen, Kumar; Sreedharan, Sandeep,*; Polachirakkal, Zachariah Paul; Shashindran, Nandita1; Mathew, Anil; Kumar, V. Ani1; Kurian, George; Nair, Rajesh R.. Varying Presentations of Pulmonary Nocardiosis in Kidney Transplant Recipients - Case Series. Indian Journal of Transplantation 15(3):p 275-278, Jul–Sep 2021.
Ramakrishna, Manjunath P.; Arun, Chankramath S.; Sreedharan, Sandeep1,*; Pavithran, Praveen V.; Bhavani, Nisha; Bhaskaran, Renjitha1; Kumar, Harish2. Changes in Bone Mineral Density in Patients Undergoing Kidney Transplantation. Indian Journal of Transplantation 15(3):p 199-204, Jul–Sep 2021.
Talwar, Surabhi; Nair, Rajesh,*; Sreedharan, Sandeep; Mathew, Anil; Paul, Zachariah; Kurian, George. Prevalence of Posttransplant Anemia in Patients Undergoing Renal Transplantation at a Tertiary Care Center in Kerala - A Prospective Observational Study. Indian Journal of Transplantation 15(2):p 93-98, Apr–Jun 2021.
Posters/ Abstracts
In International Conferences
- Tacrolimus induced hepatic veno occlusive disease in renal transplant patient. Kidney International Reports 2021; 6, S311
- Post transplant malignancy - our experience. 57th ERA-EDTA Congress abstract Nephrology Dialysis Transplantation 2020; 35( Suppl 3), P1769
- Tropical fever associated acute kidney injury-risk prediction model in a resource limited setting in South India. Nephrology Dialysis Transplantation2020; 35, 2928
- Lupus Nephritis in children and adults from a resource limited setting-a clinicopathological comparison Kidney International Reports< 2020;5 (3), S172-S173
- Hand transplant in a tertiary care hospital in India - Transplant International,< 2019; 32 (Suppl. 2); 72
- Clinical profile and risk factors of new onset diabetes after transplantation (NODAT): a single centre experience. Diabetologia,< 2019; 62: S548
- Simultaneous pancreas-kidney transplantation in a tertiary care centre in India. Transplant International,< 2019; 32 (Suppl. 2): 384
- Lupus nephritis–clinicopathological correlation and renal outcome. Lupus Science & Medicine 2018; 5 (Suppl. 1): 124-125
- Immunosuppression in India's first bilateral composite tissue transplants (hand). Transplant International 2017; 30: 379
- Study on the impact of renal status in the outcome of patients undergoing liver transplant at a tertiary care centre in South India. Nephrology Dialysis Transplantation< 2017; 32 (3), iii531-iii531
- CD68 mRNA in subcutaneous adipose tissue from lean Asian Indians indicates inflammation resembling obesity. Obesity Research 2005; 13: A168
- Subcutaneous adipose tissue mRNAs from lean Asian Indians resemble those of obese but not lean Caucasians. Obesity Research< 2005; 13: A12